Journal
NATURAL PRODUCT RESEARCH
Volume 32, Issue 15, Pages 1769-1774Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1402315
Keywords
Garcinia mangostana; xanthone dimer; garmoxanthone; antibacterial
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Funding
- International Science & Technology Cooperation Program of China [2015DFA20500]
- Scientific Research Foundation of Third Institute of Oceanography SOA [2017001]
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A novel xanthone dimer derivative, garmoxanthone (1), together with 10 known compounds (2-11), were isolated from bark of Garcinia mangostana. Their structures were established through spectroscopic methods. Garmoxanthone exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of both 3.9 mu g/mL) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15.6 to 31.2 mu g/mL). Garmoxanthone is a unique xanthone dimer with linkage of a fused 5/6 ring system and its absolute configuration was elucidated on the basis of experimental and calculated electronic circular dichroism. Garmoxanthone exhibited strong antibacterial activity which partially validated the ethnobotanical use of G. mangostana in the treatment of infections. [GRAPHICS] .
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