Journal
NATURAL PRODUCT RESEARCH
Volume 32, Issue 24, Pages 2922-2927Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1395429
Keywords
Nauclea orientalis; indole alkaloid; nauclorienine; cytotoxicities
Categories
Funding
- Applied Technology Research and Development and Demonstration Project of Hainan Province [ZDXM2015063]
- National Natural Science Foundation of China [21302181, 21662011, 31660097]
- Key Research and Development Project of Hainan Province [ZDYF2016221]
- Program of Hainan Association for Science and Technology Plans to Youth RD Innovation [HAST201636]
- Program for Innovative Research Team in University [IRT16R19]
- Natural Science Foundation of Hainan Province [20162021, 20162024]
Ask authors/readers for more resources
A new indole alkaloid, nauclorienine (1), along with seven known alkaloids (2-8), were isolated from the stems and leaves of Nauclea orientalis. Among them, nauclorienine (1) was a new indole alkaloid holding a rare corynanthe-type skeleton, and the known compounds (2-8) were isolated from N. orientalis for the first time. Their structures were elucidated on the basis of extensive spectroscopic data analyses. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1-4 exhibited significant inhibitory effects against various human cancer cell lines with IC50 values comparable to those of cisplatin. [GRAPHCIS].
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available