Journal
NATURAL PRODUCT RESEARCH
Volume 32, Issue 4, Pages 418-424Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1315574
Keywords
Holarrhena antidysenterica; chemical constituents; isolation; identification; peristalsis inhibitory
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Funding
- Student Innovation Training Program of Shenyang Pharmaceutical University
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Eight compounds were isolated from the seeds of Holarrhena antidysenterica Wall.ex A.DC. On the basis of physico-chemical properties and spectroscopic data, holarrhenanan (1) was identified as a new compound, compounds 2-3 were isolated from H. antidysenterica for the first time, and five known compounds were also obtained. Inhibitory effects of some compounds and extracts to the intestinal peristalsis were evaluated. Results showed that the extracts and compounds 4, 6 exhibited remarkable inhibitory effects with tension inhibition rate of 32.77, 32.77% and amplitude inhibition rate of 59.51, 55.98%, respectively on the vitro rabbit intestinal peristalsis. [GRAPHICS] .
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