Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 22, Pages 2634-2640Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1289202
Keywords
Solanaceae; lignans; coumarin; RAW 264.7; structure-activity relationships
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Funding
- Changjiang Scholars Back-Up Program of Heilongjiang Universities Colleges [2013CJHB006]
- Research Program of Chinese Medicine of Heilongjiang [ZHY16-091]
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Twenty-one phenylpropanoids, including 1 new (1) and 20 known phenylpropanoids (2-21), were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra referring to the literatures, together with mass spectrometry. It was found that the isolated compounds, except for 7, 18 and 19, showed the different levels of inhibitions on NO production by LPS-induced RAW 264.7 cells at IC50 values from 27.0 to 97.3 mu M. [GRAPHICS] .
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