Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 17, Pages 2016-2023Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1272113
Keywords
Aconitum sinchiangense WTWang; diterpenoid alkaloids; sinchiangensine A; antitumor activity; antibacterial activity
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Funding
- National Natural Science Foundation of China [81402816]
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A phytochemical study of the root barks of Aconitum sinchiangense W. T. Wang, a traditional Chinese herb medicine, led to the isolation of 15 diterpenoid alkaloids, including one new C-19-diterpenoid alkaloid, sinchiangensine A (1), whose structure was determined by spectral methods including 2D NMR. Additionally, sinchiangensine A and its known analogue 3 were first reported as potential antitumor and antibacterial diterpenoid alkaloids, which showed significant antitumor activities against tumour cells (HL-60, A-549, SMCC-7721, MCF-7 and SW480), with IC50 comparable to cisplatin, and significant antibacterial activities against Staphylococcus aureus ATCC-25923 with MIC value of 0.147 and 0.144 mu mol/mL, respectively.
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