Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 6, Pages 803-807Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1410811
Keywords
Vitis vinifera; unripe grapes; waste material from cluster thinning; flavan-3-ols; antifungal activity
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Funding
- Region of Apulia (PO FESR-FSE 2007-20013-Project TEGUVA) [61/09]
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The antifungal activity of unripe grape extracts from agro-industrial wastes has been evaluated against several strains of Candida spp. and dermatophytes. All the extracts tested showed antifungal activity. The geometric mean MIC ranged from 53.58 to 214.31 mu g/mL for Candida spp. and from 43.54 to 133.02 mu g/mL for dermatophytes. The chemical analyses have been carried out using Liquid Chromatograph equipped with a DAD and MS detectors. Flavan-3-ols were the main metabolites within all samples ranged from 3.3 to 6.8 mg/g fresh weight. For Candida spp. highest negative significant correlation has been found between MICs and polymeric flavan-3-ols (r = -0.842; p < 0.001) and for dermatophytes between MICs and caffeoyl derivatives (r = -0.962; p < 0.01). The results indicate that total extracts obtained from unripe grapes, a large source of waste material derived from the wine industry, could be used as a cheap source of value-added products. [GRAPHICS] .
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