4.4 Article

Cytotoxic withanolides from Physalis angulata

Journal

NATURAL PRODUCT RESEARCH
Volume 32, Issue 6, Pages 676-681

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1338281

Keywords

Withanolides; Physalis angulata L; Cytotoxic activity

Funding

  1. National Natural Science Foundation of China [81430092]
  2. Outstanding Youth Fund of the Basic Research Program of Jiangsu Province [BK20160077]
  3. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

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A new withanolide (1), physagulide P, together with five known withanolides (2-6), was isolated from the aerial parts of Physalis angulata L. The structure of new compound was elucidated on the basis of extensive spectroscopic techniques, including 1D, 2D NMR and HRESIMS. The activity screening indicated that compound 1 showed significant cytotoxicities against the human osteosarcoma cell line MG-63, HepG-2 hepatoma cells and breast cancer cells MDA-MB-231 with the IC50 value of 3.50, 4.22 and 15.74 mu M.

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