Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 21, Pages 2537-2543Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1323210
Keywords
Cordyceps militaris; ribonucleotide; nuclear factor-kappa B (NF-kappa B)
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Funding
- National Natural Science Foundation of China [81260474, 81660699, 81660579]
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One new ribonucleotide, 5'-(3 ''-deoxy-beta-D-ribofuranosyl)-3'-deoxyadenosine (1), and 14 known compounds (2-15) were isolated from an ethanol extract of Cordyceps militaris. The chemical structures of these compounds were determined from 1D and 2D NMR (H-1-H-1 COSY, HMBC, HMQC and NOESY) and HR-ESI-MS spectra, and results were compared with data from the literature. The effects of all isolated compounds were measured on NF-kappa B activation, with compound 2 exhibiting significant inhibitory activity against TNF-alpha-induced NF-kappa B reporter gene expression in HeLa cells from 3 to 100 mu M. [GRAPHICS] .
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