A new ribonucleotide from Cordyceps militaris

One new ribonucleotide, 5'-(3 ''-deoxy-beta-D-ribofuranosyl)-3'-deoxyadenosine (1), and 14 known compounds (2-15) were isolated from an ethanol extract of Cordyceps militaris. The chemical structures of these compounds were determined from 1D and 2D NMR (H-1-H-1 COSY, HMBC, HMQC and NOESY) and HR-ESI-MS spectra, and results were compared with data from the literature. The effects of all isolated compounds were measured on NF-kappa B activation, with compound 2 exhibiting significant inhibitory activity against TNF-alpha-induced NF-kappa B reporter gene expression in HeLa cells from 3 to 100 mu M. [GRAPHICS] .