Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 10, Pages 1406-1414Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1419229
Keywords
Lawsonia inermis; bioguided fractionation; phenolic glycoside; A beta(42) aggregation; Alzheimer disease; Antioxidant
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Funding
- Tunisian Ministry of Higher Education and Scientific Research
- ANCC-COOP/Airalzh ONLUS trough University of Florence [0043966.30-10-2014-u, D.R.595/2016]
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Mounting evidence indicates free radicals as toxic species causing damage to human cells leading to the pathogenesis of many diseases such as neurodegenerative disease. Plant derived antioxidants are considered as promising strategy to prevent free radical toxicity. In this study, the crude extract (CE), 50%MeOH, Petroleum Ether (PE) and Ethyl acetate (EA) fractions of Lawsonia inermis leaves were investigated for their antioxidant activity and their ability to counteract amyloid-beta(42) (A beta(42)) aggregation. Elution of the most bioactive fraction (EA) on silica gel column chromatography led to six sub-fractions. The most active sub-fraction (1) was further resolved on silica gel column chromatography. A new compound with powerful antioxidant and anti-A beta(42) aggregation properties was purified and characterised by spectroscopic methods as 1,2,4-trihydroxynaphthalene-2-O-beta-D-glucopyranoside (THNG). This finding suggests that the antioxidant and anti-A beta(42) aggregation activities of L. inermis leaves are strongly correlated to this compound.
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