Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 24, Pages 2936-2940Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1305380
Keywords
Cytotoxicity; growth inhibition; Euphorbia caducifolia; petroleum ether fraction; GC-MS; sulphorhodamine-B
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Funding
- Higher Education Commission, Pakistan [2149]
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Several Euphorbia species have been used in folklore as cancer remedies, however, scientific studies on the cytotoxicity (in vitro studies) of Euphorbia caducifolia are lacking. In present study, anticancer potential of E. caducifolia aerial parts ethanol extract and its fractions were evaluated against human lung (NCI-H460), breast (MCF-7), prostate (PC-3) and cervical (HeLa) cancer cell lines, using sulphorhodamine-B in vitro cytotoxicity (in vitro studies) assay. The ethanol extract demonstrated growth inhibitory effect against all aforementioned cancer cell lines with IC50, 19-135g/mL and LC50, 220g/mL, and its petroleum ether fraction obtained on bioactivity guided fraction showed highest activity with IC50, 28-70g/mL and LC50, 71g/mL against NCI-H460 and MCF-7 cell lines. Its phytochemicals were analysed by gas chromatography-mass spectrometry (GC-MS). The present study provides scientific justification for its traditional use against cancer. [GRAPHICS]
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