Journal
NANOTECHNOLOGY
Volume 28, Issue 28, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aa757f
Keywords
miR-210; cancer therapy; miRNA delivery; breast cancer; cell targeting
Funding
- National Natural Science Foundation of China [21603196, 31501036]
- Young Elite Scientist Sponsorship Program by CAST
- Natural Science Foundation of Hubei Province [2015CFB697]
- Fundamental Research Funds for the Central Universities, China University of Geosciences (Wuhan) [CUG170601, CUGL170406]
- State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (Wuhan University of Technology)
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MicroRNAs (miRNAs), small non-coding RNAs, play an important role in modulating cell proliferation, migration, and differentiation. Since miRNAs can regulate multiple cancer-related genes simultaneously, regulating miRNAs could target a set of related oncogenic genes or pathways. Owing to their reduced immune response and low toxicity, miRNAs with small size and low molecular weight have become increasingly promising therapeutic drugs in cancer therapy. However, one of the major challenges of miRNAs-based cancer therapy is to achieve specific, effective, and safe delivery of therapeutic miRNAs into cancer cells. Here we provide a strategy using three-layered polyplex with folic acid as a targeting group to systemically deliver miR-210 into breast cancer cells, which results in breast cancer growth being inhibited.
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