Journal
NANOTECHNOLOGY
Volume 28, Issue 42, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aa839c
Keywords
photothermal-chemotherapy; glutathione responsive micelles; semiconducting polymer dots; doxorubicin
Funding
- Natural Science Foundation of China [61575156, 61335012]
- China Postdoctoral Science Foundation [2015M571959]
- Science Foundation of Fujian provinces [2015Y0056]
- Scientific Foundation of Fuzhou City [2014-S-139-6, 2016-S-124-11]
- Scientific Foundation of the Fujian provincial Health and Family Planning Commission [2014-1-75]
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Nanoplatform integrated with photothermal therapy (PTT) and chemotherapy has been recognized a promising agent for enhancing cancer therapeutic outcomes, but still suffer from less controllability for optimizing their synergistic effects. We fabricated glutathione (GSH) responsive micelles incorporated with semiconducting polymer dots and doxorubicin (referred as SPDOX NPs) for combining PTT with chemotherapy to enhance cancer therapeutic efficiency. These micelles, with excellent water dispersibility, comprises of three distinct functional components: (1) the monomethoxy-poly(ethylene glycol)-S-S-hexadecyl (mPEG-S-S-C16), which forms the micelles, can render hydrophobic substances water-soluble and improve the colloidal stability; (2) disulfide linkages can be cleaved in a reductive environment for tumor specific drug release due to the high GSH concentrations of tumor micro-environment; (3) PCPDTBT dots and anti-cancer drug DOX that are loaded inside the hydrophobic core of the micelle can be applied to simultaneously perform PTT and chemotherapy to achieve significantly enhanced tumor killing efficiency both in vitro and in vivo. In summary, our studies demonstrated that our SPDOX NPs with simultaneous photothermal-chemotherapy functions could be a promising platform for a tumor specific responsive drug delivery system.
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