Journal
NANOSCALE RESEARCH LETTERS
Volume 12, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1186/s11671-017-2324-1
Keywords
Methotrexate; Chondroitin sulfate; Self-assembly; Nanogels; Anti-tumor; Nanomedicine; Nanotechnology
Funding
- National Natural Science Foundation [81201364, 81328015]
- Science and Technology Department of Jiangsu Province [BE2017689]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.
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