Journal
NANOSCALE
Volume 9, Issue 34, Pages 12295-12301Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr03940a
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Funding
- National Natural Science Foundation of China [81761148028]
- Science and Technology Commission of Shanghai Municipality [15520711400, 17540712000]
- Fundamental Research Funds for the Central Universities
- Science and Technology Project of Shanghai Songjiang District [16SJGG44]
- FCT-Foundation for Science and Technology (CQM, Portuguese Government) [PEst-OE/QUI/UI0674/2013]
- Madeira Chemistry Center - CQM + (Madeira) [M1420-01-0145-FEDER-000005]
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We report the synthesis and characterization of antifouling zwitterion carboxybetaine acrylamide (CBAA)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for enhanced CT imaging applications. The CBAA-modified nanodevice displays a better protein resistance property, less macrophage cellular uptake and liver accumulation, and longer blood half-delay time than the PEGylated counterpart material, thereby enabling enhanced blood pool, lymph node, and tumor CT imaging.
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