Journal
NANOSCALE
Volume 9, Issue 25, Pages 8825-8833Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr02922e
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Funding
- National Natural Science Foundation of China [51673053]
- Key Technologies R & D Program of Heilongjiang Province [GA14A101]
- Fundamental Research Funds for the Central Universities [HIT. IBRSEM. 2013016]
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The wonderful chemical structures and characteristics of low-dimensional carbon materials have exciting applications in life sciences. In the present study, we developed a facile strategy to conjugate C-60 with graphene via host-guest chemistry for targeted phototherapy. A versatile carrier based on folic acid-functionalized graphene (GO-FA) and comprising.-cyclodextrin (gamma-CD) at its surface was assembled via Pi-Pi interaction, creating hybrid structures with drug storage and tumor targeting properties. This gamma-CD-modified graphene (GO-FA/Py-gamma-CD) is capable of hosting pristine C60 molecules for the fabrication of a GO-FA/Py-gamma-CD/ C-60 nanohybrid. The hybridization of GO-FA, gamma-CD, and C-60 hinders the aggregation of C60, promotes cellular uptake, enhances light absorption, and finally demonstrates enhanced phototherapy effects of GO-FA/Py-gamma-CD/C-60. Under Xe lamp irradiation (2 W cm(-2)) for 4 min, GO-FA/ Py-gamma-CD/C-60 simultaneously causes heating and intracellular ROS production, which further significantly reduces the cell viability to 16.2% at low content of loading (30 mu g mL(-1)). Moreover, it represents an excellent tumor killing efficiency, better than that of the other reported graphene/C-60 nanohybrids; thus, this material is suitable for applications in phototherapy of cancer.
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