Journal
NANOSCALE
Volume 9, Issue 40, Pages 15685-15695Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr05003h
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Funding
- National Natural Science Foundation of China [81573364, 81572991]
- Science and Technology Project of Henan Province [162102310510]
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The chelate copper-based anticancer drug bleomycin (BLM) is usually believed to bind metal ions especially Cu(II) to generate the activated BLM for DNA cleavage. Herein, BLM and L-menthol (LM) co-loaded hollow mesoporous Cu2-xS nanoparticles (HMCu2-xS NPs) with surface folic acid (FA) modification were formulated to construct an intelligent NIR-responsive nanoplatform for synergistic tumor targeted chemo-phototherapy. With the tumor targeting ability of the folate receptor (FR)-positive, FA-HMCu2-xS/BLM/LM could pinpoint tumor cells efficiently. Under NIR irradiation, the versatile HMCu2-xS would be bound to exploit the merits of phototherapy (including PTT and PDT-like effects) for cancer treatment. Meanwhile, benefiting from the controllable solid-liquid (S-L) phase transition feature of LM as a gatekeeper, FA-HMCu2-xS/BLM/LM offered a platform for simultaneous NIR-mediated temperature-responsive BLM and copper ion release, which further initiated the generation of the activated BLM. As a matter of course, the remarkable synergistic combination of Cu-dependent chemo-phototherapy in vitro and in vivo by such a smart all-in-one drug delivery nanoplatform developed here provided information for advancing nanotherapy in biomedical fields.
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