Journal
NANOSCALE
Volume 9, Issue 28, Pages 10117-10125Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr01982c
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Funding
- MIUR
- University of Padova, Italy, within the Strategic Project PLATFORMS [STPD089KSC]
- University of Padova, Italy, within the Project BINDER [CPDA153538]
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Nanosphere lithography coupled with reactive ion etching has been used to synthesize hexagonal ordered arrays of Au-Ag bimetallic semi-nanoshells to be used as plasmonic biosensors. The degree of lateral interaction between adjacent semi-nanoshells can be controlled by tailoring the reactive ion etching time in order to boost the global plasmonic properties through the formation of near-field hotspots, which in turn can improve the sensitivity of the biosensors. To test the efficiency of the proposed system as a biosensor, we used an established protocol for the detection of biomolecules (local sensitivity), based on the receptor-ligand approach and using the biotin-streptavidin model system. We also tested the sensitivity to a homogeneous change in the refractive index of the buffer over the sensor (bulk sensitivity). Comparing the obtained results to those of an array of nanoprisms, chosen as a benchmark, significantly higher performances both in local and bulk sensitivities have been found, in agreement with electrodynamics simulations based on finite-element methods.
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