Journal
NANOSCALE
Volume 9, Issue 10, Pages 3391-3398Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nr09321c
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Funding
- National Institutes of Health [DP5OD017898, 1R01CA169365, P30CA014520]
- Korea Health Technology R&D Project of Ministry of Health and Welfare NRF Pioneer Research Center Program [HI15C1817]
- Korean Ministry of Science, ICT and Future Planning [NRF-2014 M3C1A3017229, NRF-2015 M3C1A3056409]
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Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.
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