Journal
NANOSCALE
Volume 9, Issue 45, Pages 17717-17721Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr07197c
Keywords
-
Categories
Funding
- Collaborative Innovation Center of Suzhou Nano Science and Technology, Ministry of Science and Technology of China [2016YFA0400904]
- National Natural Science Foundation of China [21675145, U1532144]
- Major program of Development Foundation of Hefei Center for Physical Science and Technology [2016FXZY006]
Ask authors/readers for more resources
Dexamethasone (Dex) is one of the essential medicines used to treat inflammation diseases but an overdose of Dex leads to severe adverse effects. The development of a new strategy to boost the anti-inflammation efficacy of Dex is, therefore, important but remains challenging. Herein, by employing an enzyme-instructed self-assembly system, we developed an intracellular coassembly strategy to boost the anti-inflammation efficacy of Dex. Under the catalysis of alkaline phosphatase (ALP), the hydrogelator precursor Nap-Phe-Phe-Tyr(H2PO3)-OH (1p) self-assembled to form Gel 1 but dexamethasone sodium phosphate (Dp) only yielded Dex precipitates. However, subjecting equivalent amounts of 1p and Dp together to ALP-triggered coassembly was found to result in the formation of Gel 2. Cell experiments indicated that intracellular ALP-triggered coassembly of Dp with 1p extensively boosted the anti-inflammation efficacy of Dex on two types inflammatory cell models. We envision that, in the near future, our strategy of intracellular coassembly could be widely employed to boost the therapeutic effects of more drugs, while in the meantime used to alleviate the undesired adverse effects of these drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available