Journal
NANOSCALE
Volume 9, Issue 14, Pages 4677-4682Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nr08357a
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Funding
- Hong Kong Baptist University [FRG2/15-16/002]
- Health and Medical Research Fund [HMRF/14130522]
- Research Grants Council [HKBU/12301115, HKBU/204612, HKBU/201913]
- French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme [AHKBU201/12, ANR-12-IS07-0001]
- National Natural Science Foundation of China [21575121, 21628502]
- Guangdong Province Natural Science Foundation [2015A030313816]
- Hong Kong Baptist University Century Club Sponsorship Scheme
- Interdisciplinary Research Matching Scheme [RC-IRMS/15-16/03]
- Science and Technology Development Fund
- Macao SAR [098/2014/A2]
- University of Macau [MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM, MRG044/LCH/2015/ICMS]
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A rapid and sensitive detection platform for GSH has been constructed by combining a MnO2 nanosheet with a luminescent iridium(III) complex [Ir(Cl-phq)2(Cl-phen)]+. The MnO2 nanosheet was prepared by using a facile one-step approach and was characterized by TEM. The luminescence intensity of the detection platform responded linearly with the GSH concentration from 1 to 200 mu M (R-2 = 0.9951), and the detection limit for GSH was 0.13 mu M. More importantly, practical application of the detection platform for visualizing the intracellular GSH distribution in living zebrafish has also been demonstrated.
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