Journal
NANOSCALE
Volume 9, Issue 32, Pages 11429-11433Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr02499a
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Funding
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Hefei Science Center CAS [2016HSC-IU010]
- Ministry of Science and Technology of China [2016YFA0400904]
- National Natural Science Foundation of China [21675145, U1532144]
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When supramolecular hydrogels are applied as tissue culture scaffolds, their mechanical strength and biocompatibility are the two most important factors that must be considered. However, systematic studies on the structure-mechanical property (or structure-cytotoxicity) relationship of hydrogels are rare. Herein, we rationally designed three hydrogelators and their corresponding phosphate precursors, and systematically studied their self-assembling ability and cytotoxicity. The results indicated that fluorine substitution, but not trifluoromethyl substitution with more fluorine atoms, to the phenylalanine motif enhanced the self-assembling ability and cytotoxicity of the hydrogelators (or precursors). We envision that our preliminary study of hydrogelator fluorination would provide a strategy for the development of supramolecular hydrogels for wider biomedical applications.
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