Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 13, Issue 1, Pages 83-93Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2016.08.029
Keywords
Quantum dot; NGR; CD13; Brain glioma; Blood-brain barrier
Funding
- National Natural Science Foundation of China [81201066, 81371674, 81471676, 81401505]
- Chongqing Natural Science Foundation Project [CSTC2013jcyjA10054, CSTC2014 jcyjA10050]
- Medical Research Projects of Chongqing Municipal Health Bureau [2013-1-018]
- Scientific Research Project of Health Bureau in Chongqing Municipal Health Bureau Traditional Chinese Medicine Scientific Research Project [ZY201402092]
- Chongqing Medical Research Project [20141004]
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Delivery of imaging agents to brain glioma is challenging because the blood-brain barrier (BBB) functions as a physiological checkpoint guarding the central nervous system from circulating large molecules. Moreover, the ability of existing probes to target glioma has been insufficient and needs to be improved. In present study, PEG-based long circulation, CdSe/ZnS quantum dots (QDs)-based nanoscale and fluorescence, asparagines-glycine-arginine peptides (NGR)-based specific CD13 recognition were integrated to design and synthesize a novel nanoprobe by conjugating biotinylated NGR peptides to avidin-PEG-coated QDs. Our data showed that the NGR-PEG-QDs were nanoscale with less than 100 nm and were stable in various pH (4.0 similar to 8.0). These nanomaterials with non-toxic concentrations could cross the BBB and target CD13-overexpressing glioma and tumor vasculature in vitro and in vivo, contributing to fluorescence imaging of this brain malignancy. These achievements allowed groundbreaking technological advances in targeted fluorescence imaging for the diagnosis and surgical removal of glioma, facilitating potential transformation toward clinical nanomedicine. (C) 2016 Elsevier Inc. All rights reserved.
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