Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 7, Pages 2465-2474Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.02.022
Keywords
Two-dimensional (2D) nanomaterials; Osteochondral (bone-cartilage) interface; Tissue engineering; Hydrogels; Gradient scaffold; Nanocomposites
Funding
- Texas A&M University Diversity Fellowship
- National Institute of Health [R03-EB023454-01A1]
- Texas Engineering Experiment Station
- Texas A&M University Seed Grant
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R03EB023454] Funding Source: NIH RePORTER
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Two-dimensional (2D) nanomaterials are an emerging class of materials with unique physical and chemical properties due to their high surface area and disc-like shape. Recently, these 2D nanomaterials have been investigated for a range of biomedical applications including tissue engineering, therapeutic delivery and bioimaging, due to their ability to physically reinforce polymeric networks. Here, we present a facile fabrication of a gradient scaffold with two natural polymers (gelatin methacryloyl (GelMA) and methacrylated kappa carrageenan (M kappa CA)) reinforced with 2D nanosilicates to mimic the native tissue interface. The addition of nanosilicates results in shear-thinning characteristics of prepolymer solution and increases the mechanical stiffness of crosslinked gradient structure. A gradient in mechanical properties, microstructures and cell adhesion characteristics was obtained using a microengineered flow channel. The gradient structure can be used to understand cell-matrix interactions and to design gradient scaffolds for mimicking tissue interfaces. (C) 2017 Elsevier Inc. All rights reserved.
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