Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 13, Issue 8, Pages 2587-2596Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.07.007
Keywords
Silver nanoparticles; Diabetic rats; Nitric oxide; Oxidative stress
Funding
- Consejo Nacional de Ciencia y Tecnologia [318669]
- [C15-FAI-04-33.33]
- [C15-PIFI-06-02.02]
- [C16-PIFI-09-08.08]
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Silver nanoparticles (AgNPs) are promising antibacterial nanomaterials for diagnostic and treatment of diabetes. However, toxicity and adverse cardiac responses induced by AgNPs related to nitric oxide (NO) and oxidative stress (OS) are described. Moreover, little is known about the diabetes influence upon AgNPs-toxicity. The aim of this work was to evaluate cardiovascular function in response to AgNPs through measuring perfusion pressure (PP) and left ventricle pressure (LVP), using perfused hearts from streptozotocin (STZ)-induced diabetic rats and identify the role of NO and OS. High concentrations but not the lower concentrations of AgNPs, promotes increases in PP and LVP, as well as increased OS. Additionally, diabetes alters the classic effects of phenylephrine (Phe) and acetylcholine (ACh). These data suggest that diabetes may intensify AgNPs-cardiotoxicity. Nevertheless, the precise mechanism of action is still under elucidation. (C) 2017 Elsevier Inc. All rights reserved.
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