Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 13, Issue 6, Pages 1965-1974Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.05.002
Keywords
Diabetes mellitus; Insulin; Oral delivery; Selenium nanoparticles; Hypoglycemic effect
Funding
- National Natural Science Foundation of China [81673604]
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Oral insulin delivery has been plagued by limited bioavailability. This work reports selenium nanoparticles (SeNPs) for oral insulin delivery to overcome the absorption barrier. Insulin-loaded SeNPs (INS-SeNPs) were fabricated by ionic cross-linking/in situ reduction and characterized by particle size and drug entrapment. The resultant INS-SeNPs were 120 nm around in particle size with high drug loading. INS-SeNPs exhibited controllable insulin release and outstanding stability in the digestive fluids. INS-SeNPs caused a significant hypoglycemic effect in both normal and diabetic rats. The pharmacological bioavailability was up to 9.15% relative to subcutaneous insulin. Likewise, the blood insulin evidently increased in terms of INS-SeNPs. Ex vivo intestinal imaging and cell experiments showed the excellent performance of INS-SeNPs in intestinal permeability. INS-SeNPs could alleviate oxidative stress, improve pancreatic islet function, and promote glucose utilization. Our study provides proof of concept for using SeNPs to orally deliver insulin, jointly potentiating the antidiabetic effect. (C) 2017 Elsevier Inc. All rights reserved.
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