Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 13, Issue 6, Pages 1941-1952Publisher
ELSEVIER
DOI: 10.1016/j.nano.2017.03.014
Keywords
Colorectal tumors; Endoscopic; Mesoporous silica nanoparticle; Ulex europaeus Agglutinin 1 (UEA1)
Funding
- National Health Research Institutes of Taiwan [BN-103-PP-04, NM-103-PP-01]
- National Science Council/Ministry of Science and Technology of Taiwan [NSC-100-2911-I-400-502, NSC-100-2917-I-002-030, NSC102-2113-M-400-001-MY3, MOST105-2113-M-400-007-MY3, MOST106-2113-M-039-002-MY2]
- China Medical University, Taiwan [CMU105-N-11]
- NIH/NCI [R01CA171785, CA036745]
- NIH/NCCAM [AT004418, AT005362]
- Samuel Freedman Research Laboratories for Gastrointestinal Cancer Research
- University of Chicago Comprehensive Cancer Center
Ask authors/readers for more resources
Colorectal cancer (CRC) is one of the leading causes of cancer-deaths worldwide. Methods for the early in situ detection of colorectal adenomatous polyps and their precursors-prior to their malignancy transformation into CRC-are urgently needed. Unfortunately at present, the primary diagnostic method, colonoscopy, can only detect polyps and carcinomas by shape/morphology; with sessile polyps more likely to go unnoticed than polypoid lesions. Here we describe our development of polyp-targeting, fluorescently-labeled mesoporous silica nanoparticles (MSNs) that serve as targeted endoscopic contrast agents for the early detection of colorectal polyps and cancer. In vitro cell studies, ex vivo histopathological analysis, and in vivo colonoscopy and endoscopy of murine colorectal cancer models, demonstrate significant binding specificity of our nanoconstructs to pathological lesions via targeting aberrant a-L-fucose expression. Our findings strongly suggest that lectin-functionalized fluorescent MSNs could serve as a promising endoscopic contrast agent for in situ diagnostic imaging of premalignant colonic lesions. (C) 2017 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available