4.7 Article

Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow

Journal

NANOMEDICINE
Volume 12, Issue 22, Pages 2725-2740

Publisher

FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0211

Keywords

blood flow; gold nanoparticles; imaging; luminescence; metal probes

Funding

  1. EPSRC [EP/F50053X/1]
  2. Leverhulme Trust
  3. University of Birmingham
  4. Advantage West Midlands (AWM)
  5. European Regional Development Fund (ERDF)
  6. Engineering and Physical Sciences Research Council [EP/G032262/1, 965133, 1362876, 1239482] Funding Source: researchfish
  7. EPSRC [EP/G032262/1] Funding Source: UKRI

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Aim: Imaging of blood flow in narrow channels and close to vessel walls is important in cardiovascular research for understanding pathogenesis. Our aim was to provide novel nanoprobes with visible emission and long lifetimes as trackers of flow. Materials & methods: Gold nanoparticles coated with an iridium complex were prepared. Luminescence imaging was used to monitor their flows in different hematocrit blood and in murine tissues. Results: The velocities are independent of hematocrit level and the nanoparticles entering blood circulation can be clearly detected in vessels in lungs, mesentery and the skeletal muscle. Conclusion: The work introduces for the first time iridium-based yellow-green luminescence with nanoparticle size of 100 nm for visualizing and monitoring flows with much higher resolution than conventional alternatives.

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