Journal
NANOMEDICINE
Volume 12, Issue 9, Pages 991-1009Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0027
Keywords
magnetic resonance; nanobubble; PEGlyated PLGA; photoacoustic; target; ultrasound
Funding
- National Nature Science Foundation of China [30970752, 81130025, 81571663]
- program for Innovation Team Building at Institutions of Higher Education in Chongqing [KJTD201303]
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The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. Materials & methods: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIOHER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging. Results: PTX-USPIO-HER-NBs exhibited excellent entrapment efficiency of Herceptin/PTX/USPIO and showed greater cytotoxic effects than other delivery platforms. Low-frequency ultrasound triggered accelerated PTX release. Moreover, the magnetic nanobubbles were able to enhance ultrasound, magnetic resonance and photoacoustics trimodal imaging. Conclusion: These results suggest that PTX-USPIO-HER-NBs have potential as a multimodal contrast agent and as a system for ultrasound-triggered drug release in breast cancer.
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