Journal
NANOMEDICINE
Volume 12, Issue 12, Pages 1435-1453Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0036
Keywords
cancer; chitosan; cholesterol; curcumin; micelles; nanocarrier; spheroid
Funding
- Department of Science and Technology, Government of India [CS-269/2013]
- Department of Biotechnology, Government of India [BT/Bio-CARe/07/10003/2013-14]
- Indian Council of Medical Research, Department of Health Research, Ministry of Health and Family Welfare, Government of India [2014-24190]
Ask authors/readers for more resources
Aim: To improve the bioavailability and anticancer potential of curcumin by using a cholesterol-conjugated chitosan micelle. Methods & methods: Cholesterol was conjugated to chitosan (15 kDa) to form self-assembled micelles, which loaded curcumin. Physicochemical characterization and formulation optimization of the drug-loaded micelles (curcumin-loaded chitosan-cholesterol micelles [C-CCM]) were performed. In vitro cellular uptake and viability of C-CCM were investigated in melanoma and breast cancer cell lines. The antitumor efficacy was evaluated in 3D lung cancer spheroid model. Results & conclusion: The optimized C-CCM had size of approximately 162 nm with loading efficiency of approximately 36%. C-CCM was taken up efficiently by the cells, and it reduced cancer cell viability significantly compared with free curcumin. C-CCM enhanced the antitumor efficacy in spheroids, suggesting that C-CCM could be used as an effective chemotherapy in cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available