Journal
NANOMEDICINE
Volume 12, Issue 5, Pages 473-490Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0371
Keywords
chitosan; drug delivery; hyaluronan; layer-by-layer; multidrug resistance; nanoncology; paclitaxel; solid lipid nanoparticles
Funding
- Faculty of Dentistry, Universidad de los Andes, Santiago de Chile
- PMI (Plan de Mejoramiento Institucional), I+D+i, Direccion de Innovacion, Universidad de los Andes, Santiago de Chile
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Aim: To investigate the potential of modified solid lipid nanoparticles (SLN) for the delivery of paclitaxel (PAX). Materials & methods: SLN loaded with PAX were prepared via modified high-pressure hot homogenization. Formulation parameters were optimized to obtain a high-quality delivery system. SLN cores were coated, layerby-layer, with a chitosan and hyaluronan (HA) shell. Selectivity toward HA receptors was tested in a breast cancer cell line, MCF-7. Results: Stable and reproducible nano-sized and negatively charged nanoparticles resulted. Findings reveal that chitosan-HA-coated SLN facilitated the targeting, cellular uptake and the time-/dose- controlled delivery and release of PAX, enhancing intrinsic chemotherapeutic activities. Conclusion: SLN are suitable carrier candidates for nano-oncology given their localized, and potent cytotoxic potential overcoming multidrug-resistant cancer cells.
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