Journal
NANOMEDICINE
Volume 12, Issue 16, Pages 1945-1959Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0088
Keywords
cancer; immunotherapy; nanoliposome(s); pH responsive; targeting
Funding
- Indian Council of Medical Research (ICMR)
- UGC-BSR, New Delhi, India
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Aim: The purpose of present approach is to target C-Type lectin (CTL) receptors for preferential uptake by the macrophages/dendritic cells and improving the cross-presentation of ovalbumin. Materials & methods: Conventional and engineered nanoliposomes (MPNLs) were fabricated and extensively characterized. The nanoliposome(s) was spherical in shape; and their. potential, size and ovalbumin loading efficiency were recorded to be 268 +/- 4.15 nm, 23.4 +/- 0.35 mV, 46.65 +/- 1.84%, respectively. Results: The findings demonstrate that MPNLs significantly improved the antigen uptake and its cross-presentation to evoke Th CD8(+) cell-mediated cellular immunity. Conclusion: In a nutshell, this engineered approach mannose surface modification for active targeting to dendritic cells/macrophages and pH-dependent quick endosomal antigen release is a promising system for efficient cancer immunotherapy.
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