Journal
NANOMEDICINE
Volume 12, Issue 19, Pages 2403-2422Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0173
Keywords
nanotechnology; skin; smart dressings; stem cells; tissue engineering; wound healing
Funding
- US NIH [R01AI050875, R21AI121700]
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Skin is the outermost covering of the human body and at the same time the largest organ comprising 15% of body weight and 2 m(2) surface area. Skin plays a key role as a barrier against the outer environment depending on its thickness, color and structure, which differ from one site to another. The four major types of problematic wounds include ulcers (diabetic, venous, pressure) and burn wounds. Developing novel dressings helps us to improve the wound healing process in difficult patients. Recent advances in regenerative medicine and nanotechnology are revolutionizing the field of wound healing. Antimicrobial activity, exogenous cell therapy, growth factor delivery, biodegradable and biocompatible matrix construction, all play a role in hi-tech dressing design. In the present review, we discuss how the principles of regenerative medicine and nanotechnology can be combined in innovative wound dressings.
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