Journal
NANOMEDICINE
Volume 12, Issue 22, Pages 2771-2785Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0172
Keywords
antibacterial; biocompatibility; chitosan; electrospinning; silver nanoparticles
Funding
- NutsOhra Foundation in the Netherlands [1303-024]
- National Medical Research Council of Singapore [NMRC/CG/008/2013]
- Chinese Scholarship Council [201406220180]
Ask authors/readers for more resources
Aim: To evaluate the antibacterial potential and biological performance of silver nanoparticles in chitosanbased membranes. Materials & methods: Electrospun chitosan/poly(ethylene oxide) membranes with different amounts of silver nanoparticles were evaluated for antibacterial properties and cytotoxicity in vitro and for tissue response in a rabbit subcutaneous model. Results: The nanoparticles displayed dose-dependent antibacterial properties against Porphyromonas gingivalis and Fusobacterium nucleatum, without showing noticeable cytotoxicity. The membranes with silver nanoparticles evoked a similar inflammatory response compared with the membranes without silver nanoparticles. Conclusion: The antibacterial effect, combined with the findings on cyto- and biocompatibility warrants further investigation to the usefulness of chitosan/poly(ethylene oxide) membranes with silver nanoparticles, for clinical applications like guided tissue regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available