Journal
NANOMEDICINE
Volume 12, Issue 3, Pages 255-269Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0331
Keywords
liposomes; mucopenetrating nanoparticles; nanocarriers; oral drug delivery; polymeric nanoparticles; polymeric micelles; pre-uptake metabolism; self-emulsifying drug delivery systems; solid lipid nanoparticles
Funding
- ASEAN-European Academic University Network (ASEA Uninet) - Austrian Federal Ministry of Science, Research and Economy (BMWFW)
- BIONORICA-Stipendium
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Pre-uptake metabolism within the GI tract is responsible for the poor oral bioavailability of numerous drugs. As nanocarriers function as a 'shield', protecting incorporated drugs from enzymatic attack, there is an increasing interest in utilizing them as a tool for overcoming drug degradation. Degradation of carriers resulting in the release of incorporated drugs, mucus permeation, enzyme inhibitory properties and their toxicity are crucial factors that must be taken into account when designing proper nanocarriers. The use of polymer-and lipid-based nanocarriers as protective vehicles are discussed within this review. Lipid-based carriers and novel mucopenetrating particles seem to have a great potential in avoiding metabolizing enzymes. Accordingly, nanocarriers are promising tools for improving the bioavailability of drugs, being sensitive to a pre-uptake metabolism.
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