Journal
NANOMEDICINE
Volume 12, Issue 7, Pages 711-728Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0388
Keywords
glabrescione B (GlaB); Hedgehog (Hh) pathway; oil-cored polymeric nanocapsules
Funding
- COST Action [CM-1407]
- BBSRC [BB/M018040/1] Funding Source: UKRI
- MRC [MR/K017047/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M018040/1] Funding Source: researchfish
- Cancer Research UK [16399, 17368] Funding Source: researchfish
- Medical Research Council [MR/K017047/1] Funding Source: researchfish
- The Brain Tumour Charity [8/105] Funding Source: researchfish
- Worldwide Cancer Research [12-1054] Funding Source: researchfish
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With the purpose of delivering high doses of glabrescione B (GlaB) to solid tumors after systemic administration, long-circulating GlaB-loaded oil-cored polymeric nanocapsules (NC-GlaB) were formulated. Materials & methods: Synthesis of GlaB and its encapsulation in nanocapsules (NCs) was performed. Empty and GlaB-loaded NCs were assessed for their physico-chemical properties, in vitro cytotoxicity and in vivo biodistribution. Results: GlaB was efficiently loaded into NCs (similar to 90%), which were small (similar to 160 nm), homogeneous and stable upon storage. Further, GlaB and NC-GlaB demonstrated specific activities against the cancer stem cells. Preliminary studies in tumor-bearing mice supported the ability of NC to accumulate in pancreatic tumors. Conclusion: This study provides early evidence that NC-GlaB has the potential to be utilized in a preclinical setting and justifies the need to perform therapeutic experiments in mice.
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