Journal
NANO RESEARCH
Volume 11, Issue 1, Pages 195-205Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-017-1619-y
Keywords
two-dimensional; nanomaterials; monolayer; layered double hydroxide (LDH); drug loading; controllable release
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Funding
- National Natural Science Foundation of China (NSFC) [21671013, 21601010]
- National Basic Research Program of China (973 Program) [2014CB932103]
- Fundamental Research Funds for the Central Universities [YS 1406, ZY1628, buctrc201611]
- Beijing Natural Science Foundation [2174082]
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Two-dimensional (2D) nanomaterials have gained tremendous attention in the field of biomedicine because of their high specific surface areas and fascinating physicochemical properties. Herein, 2D monolayered double hydroxide (MLDH) nanosheets were employed to localize doxorubicin (DOX), an anticancer drug, with a loading capacity of as high as 3.6 mg.mg(-1) (w/w). Structural characterizations and theoretical calculations indicate that the DOX molecule is uniformly arranged and oriented at the surface of the MLDHs with a binding energy of 15.90 eV, showing significant electrostatic interaction. With the assistance of the targeting agent folic acid (FA), DOX-FA/MLDHs demonstrate targeted cellular uptake and superior anticancer behavior based on in vitro tests performed with cancer cells. In addition, this composite material exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which would guarantee its practical applications in cancer therapy.
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