Journal
NANO LETTERS
Volume 17, Issue 5, Pages 3225-3230Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.7b00814
Keywords
DNA nanotechnology; molecular devices; DNA nanoswitches; DNA nanomachines; cooperativity
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Funding
- Associazione Italiana per la Ricerca sul Cancro, AIRC [14420]
- European Research Council, ERC [336493]
- Int. Research Staff Exchange Scheme (IRSES)
- National Sciences and Engineering Research Council of Canada [436381-2013]
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Here we report the rational design of a synthetic molecular nanodevice that is directly inspired from hemoglobin, a highly evolved protein whose oxygen-carrying activity is finely regulated by a sophisticated network of control mechanisms. Inspired by the impressive performance of hemoglobin we have designed and engineered in vitro a synthetic DNA-based nanodevice containing up to four interacting binding sites that, like hemoglobin, can load and release a cargo over narrow concentration ranges, and whose affinity can be finely controlled via both allosteric effectors and environmental cues like pH and temperature. As the first example of a synthetic DNA nanodevice that undergoes a complex network of nature-inspired control mechanisms, this represents an important step toward the use of similar nanodevices for diagnostic and drug-delivery applications.
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