Journal
NANO LETTERS
Volume 17, Issue 7, Pages 4096-4100Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.7b00828
Keywords
Magnetic resonance imaging; magnetic nanoparticles; protein; tumor targeting; clearance
Categories
Funding
- National Institutes of Health [R01MH103133]
- Human Frontier Science [RGY-0090/2014]
- National Natural Science Foundation of China [81472682, 81572538, 30700834]
- China Scholarship Council (CSC)
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Biocompatibility, targeting, and clearance are key challenges in the design of new MRI contrast agents. Herein, we report on a tumor-targeting, gadolinium biomineralized human transferrin (Tf) protein-based nanoparticle (Gd@Tf NP) for MRI use. As compared to the conventionally used gadolinium chelates, the resultant Gd@Tf NPs possess outstanding chemical stability and exhibited superior longitudinal relaxation. More importantly, our MR images show that Gd@Tf indeed retained the natural tumor targeting ability and the subsequent tumor retrieval biofunctions of Tf. Thus, such Tf protein-based MR NPs integrate T1 signal amplification, precise tumor targeting, and systematic clearance capabilities. They offer a new approach to design biocompatible multifunctional MRI contrast agents for a wide range of clinical imaging and treatment applications.
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