Journal
JOURNAL OF CANCER PREVENTION
Volume 23, Issue 3, Pages 117-125Publisher
KOREAN SOC CANCER PREVENTION
DOI: 10.15430/JCP.2018.23.3.117
Keywords
Microbiota; Colon; Carcinogenesis; Butyric acid; Bile acids and salts
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Funding
- National Research Foundation of Korea (NRF) - government of the Republic of Korea [2016R1A2B4013133]
- National Research Foundation of Korea [2016R1A2B4013133] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ's extensive interaction with microbes necessitated research on the role of microbiota on development of colon cancer. In this review, we summarized the defense mechanism of colon from foreign organism, and germ-free animal models that have been employed to elucidate microbial effect. We also comprehensively discussed the metabolic property of microbiota such as butyrate production, facilitation of heme toxicity, bile acid transformation, and nitrate reduction that has been shown to contribute to the development of the tumor. Finally, up-to-date subjects such as the effect of age and gender on microbiota are briefly discussed.
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