Journal
MACHINE LEARNING IN MEDICAL IMAGING: 9TH INTERNATIONAL WORKSHOP, MLMI 2018
Volume 11046, Issue -, Pages 380-388Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/978-3-030-00919-9_44
Keywords
Autosomal dominant polycystic kidney disease (ADKPD); Multi-task learning; 3D fully convolutional network (3D FCN)
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Autosomal dominant polycystic kidney disease (ADPKD) characterized by progressive growth of renal cysts is the most prevalent and potentially lethal monogenic renal disease, affecting one in every 500-1000 people. Total Kidney Volume (TKV) and its growth computed from Computed Tomography images has been accepted as an essential prognostic marker for renal function loss. Due to large variation in shape and size of kidney in ADPKD, existing methods to compute TKV (i.e. to segment ADKP) including those based on 2D convolutional neural networks are not accurate enough to be directly useful in clinical practice. In this work, we propose multi-task 3D Convolutional Neural Networks to segment ADPK and achieve a mean DICE score of 0.95 and mean absolute percentage TKV error of 3.86%. Additionally, to solve the challenge of class imbalance, we propose to simply bootstrap cross entropy loss and compare results with recently prevalent dice loss in medical image segmentation community.
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