Journal
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Volume 772, Issue -, Pages 23-35Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrrev.2016.08.001
Keywords
HPV; HPV E6; HPV E7; Cervical Cancer; Cervical Cancer Stem Cells
Funding
- Associazione Italiana per la Ricerca sul Cancro
- Arturo Falaschi ICGEB Fellowship
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Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with cervical cancer being the most important. Two viral oncoproteins, E6 and E7, are essential for the development and maintenance of malignancy. Both proteins function by targeting critical pathways that are essential for maintaining cellular homeostasis. As a consequence of these activities, this produces an environment that is favourable for the normal viral life cycle, but when perturbed, can result in the initiation of changes to the host cell, which ultimately results in the development of a malignancy. In this review we discuss the role of these different functions of the viral oncoproteins during the viral life cycle and carcinogenesis, with an emphasis on how induction of DNA damage by the viral oncoproteins, in conjunction with the stem like nature of the target cells, can ultimately result in the development of cancer. (C) 2016 Elsevier B.V. All rights reserved.
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