Journal
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Volume 780, Issue -, Pages 82-91Publisher
ELSEVIER
DOI: 10.1016/j.mrrev.2017.09.004
Keywords
Poly(ADP-ribosyl)ation; Poly(ADP-ribosyl)lation polymerase; PARylation; De-PARylation; DNA damage response; PAR recognition domain; BRCT domain; PARP inhibitor; PARP inhibitor resistance
Funding
- National Institutes of Health [CA132755, CA130899, CA187209]
- Department of Defense [BA160420]
- Leukemia and Lymphoma Society Scholar Award
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Poly(ADP-ribosyl)ation (aka PARylation) is a unique protein post-translational modification (PTM) first described over 50 years ago. PARylation regulates a number of biological processes including chromatin remodeling, the DNA damage response (DDR), transcription, apoptosis, and mitosis. The subsequent discovery of poly(ADP-ribose) polymerase-1 (PARP-1) catalyzing DNA-dependent PARylation spearheaded the field of DDR. The expanding knowledge about the poly ADP-ribose (PAR) recognition domains prompted the discovery of novel DDR factors and revealed crosstalk with other protein PTMs including phosphorylation, ubiquitination, methylation and acetylation. In this review, we highlight the current knowledge on PAR-regulated DDR, PAR recognition domain, and PARP inhibition in cancer therapy.
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