Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 24, Issue 4, Pages 512-519Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458517701588
Keywords
Multiple sclerosis; pediatric multiple sclerosis; cognition; BICAMS; Cogstate
Categories
Funding
- Lourie Foundation, Inc.
- National Multiple Sclerosis Society [10020073405]
- National Institutes of Health (NIH) [UL1 TR000002, R01NS071463]
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Background: Cognitive impairment is a common and troubling feature of pediatric-onset multiple sclerosis (POMS). Brief cognitive assessment in the outpatient setting can identify and longitudinally monitor cognitive involvement so that early intervention is possible. Objectives: The goal of this study was to measure the sensitivity of two cognitive assessment approaches that are brief, repeatable, and suitable for clinical practice and for multicenter investigation. Methods: Participants with POMS (n=69) were consecutively evaluated as part of outpatient neurologic visits and compared to healthy control participants (HC, n=66) using the Brief International Cognitive Assessment for MS (BICAMS) approach and timed information processing measures from Cogstate, a computer-based assessment. Results: There was strong agreement in the detection rate of impairment between both assessments, with 26% for the BICAMS and 27% for Cogstate. Two of the Cogstate tasks were the most sensitive individual measures. Conclusion: Both the BICAMS and Cogstate timed processing measures offer practical, sensitive, and standardized approaches for cognitive screening assessment in POMS.
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