Journal
EXPRESS POLYMER LETTERS
Volume 13, Issue 1, Pages 27-36Publisher
BUDAPEST UNIV TECHNOL & ECON
DOI: 10.3144/expresspolymlett.2019.4
Keywords
tailor made polymers; chitosan; cross-linking Diels-Alder reaction; pH-responsive hydrogels
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Funding
- Basque Country Government [IT-776-13]
- Spanish Ministry of Economy and Competitiveness (MINECO) [MAT2016-76294-R]
- University of the Basque Country (UPV/EHU) [PIF15/092]
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Polypropylene oxide)-poly(ethylene oxide)-poly(propylene oxide) (PPO-PEO PPO) based bismaleimide (BMO was employed as cross-linking agent for the synthesis of pH-sensitive clicked hydrogels by Diels-Alder (DA) reaction with furan-grafted chitosan in aqueous solution. The effect of the surrounding pH over the microstructure and the swelling ability of the hydrogels was evaluated depending on the initial composition. The results suggested that the hydrogels maintained the characteristic responsive properties of the original biopolymer even after the cross-linking reaction. The different macromolecular networks remarkably affected the final properties, especially when referring to pH-swelling sensitiveness and hydrogel porosity. In addition, the swelling parameters revealed that the hydrogels presented large liquid absorption capacity, showing excellent recovery properties and responsiveness at different pHs. The promising features of the ensuing hydrogels made them suitable as targeted pH-sensitive drug delivery systems.
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