Journal
BIOFABRICATION
Volume 11, Issue 1, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1758-5090/aae5fe
Keywords
microvascular tissue engineering; collagen; microfluidic vascularization; Intralipid; microphysiological system
Funding
- National Institute of Biomedical Imaging and Bioengineering [EB018851]
- National Cancer Institute [CA214292]
- NIH Translational Research in Biomaterials training program [EB006359]
- Undergraduate Research Opportunities Program
- Summer Term Alumni Research Scholarship at Boston University
- Lutchen Fellowship at Boston University
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Current methods to treat large soft-tissue defects mainly rely on autologous transfer of adipocutaneous flaps, a method that is often limited by donor site availability. Engineered vascularized adipose tissues can potentially be a viable and readily accessible substitute to autologous flaps. In this study, we engineered a small-scale adipose tissue with pre-patterned vasculature that enables immediate perfusion. Vessels formed after one day of perfusion and displayed barrier function after three days of perfusion. Under constant perfusion, adipose tissues remained viable and responded to lipoactive hormones insulin and epinephrine with lipid accumulation and loss, respectively. Adipocyte growth correlated inversely with distance away from the feeding vessel, as predicted by a Krogh-type model.
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