Journal
MONATSHEFTE FUR CHEMIE
Volume 148, Issue 10, Pages 1853-1863Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-017-1960-6
Keywords
Furochromones; Visnagenone; Khellinone; Quinoxalines; Pyrimidines; Pyrazolobenzofurans; Cytotoxic activity
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Funding
- Department of Photochemistry (Heterocyclic unit)
- Chemical Industries Research Division, National Research Centre in Cairo, Egypt
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A series of novel quinoxaline, pyrimidine, and pyrazole furochromone derivatives were synthesized for the first time. These derivatives were prepared under mild conditions using a stepwise efficient methodology. The developed protocol led to the synthesis of furochromone derivatives in moderate to good yields (60-75%). The structures of the prepared derivatives were identified using several spectroscopic techniques including IR, NMR, and mass spectrometry. The cytotoxic activity of the synthesized derivatives was evaluated using in vitro Ehrlich ascites assay. Pyrazolobenzofurans exhibited the most potent effect suggesting the importance of pyrazole nucleus for the cytotoxic activity. [GRAPHICS] .
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