Journal
MOLECULES
Volume 22, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules22060990
Keywords
Na/K-ATPase; Src; signal transduction; cardiotonic steroids; drug target
Funding
- NIH [HL109015]
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The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduction that are important for animal physiology and disease progression. This article will focus on the role of protein interaction in NKA-mediated signal transduction, and its potential utility as target for developing new therapeutics.
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