Journal
MOLECULES
Volume 22, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules22020287
Keywords
Ligusticum chuanxiong; polysaccharides; purification; pectic polysaccharide; complement system
Funding
- Huichuntang Pharmaceutical Co., Ltd.
- Science &Technological Department of Sichuan Province, China [2011NZ0098-12-01]
- Sichuan Agricultural University
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Rhizome of Ligusticum chuanxiong is an effective medical plant, which has been extensively applied for centuries in migraine and cardiovascular diseases treatment in China. Polysaccharides from this plant have been shown to have interesting bioactivities, but previous studies have only been performed on the neutral polysaccharides. In this study, LCP-I-I, a pectic polysaccharide fraction, was obtained from the 100 degrees C water extracts of L. chuangxiong rhizomes and purified by diethylaminethyl (DEAE) sepharose anion exchange chromatography and gel filtration. Monosaccharide analysis and linkage determination in addition to Fourier transform infrared (FT-IR) spectrometer and Nuclear magnetic resonance (NMR) spectrum, indicated that LCP-I-I is a typical pectic polysaccharide, with homo-galacturonan and rhamnogalacturonan type I regions and arabinogalactan type I and type II (AG-I/AG-II) side chains. LCP-I-I exhibited potent complement fixation activity, ICH50 of 26.3 +/- 2.2 mu g/mL, and thus has potential as a natural immunomodulator.
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