Journal
MOLECULES
Volume 22, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules22030387
Keywords
esculetin; coumarin; synthetic derivatives; pharmacological activity; molecular mechanism
Funding
- National Natural Science Foundation of China [81602967]
- China Postdoctoral Science Foundation [2016M592898XB]
- Shaanxi Postdoctrol Science Foundation
- Basic Reserch Education Department of Shaanxi Province [15JK1076]
- National College Students' Innovative Entrepreneurial Training Program [201510708172, 201610708019]
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Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. The twig skin or trunk bark of Cortex Fraxini are used by herb doctors as a mild, bitter liver and gallbladder meridians' nontoxic drug as well as dietary supplement. Recently, with a variety of novel esculetin derivatives being reported, the molecular mechanism research as well as clinical application of Cortex Fraxini and esculetin are becoming more attractive. This mini-review will consolidate what is known about the biological activities, the mechanism of esculetin and its synthetic derivatives over the past decade in addition to providing a brief synopsis of the properties of esculetin.
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