Journal
MOLECULES
Volume 22, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/molecules22050689
Keywords
processed-Ligustri Lucidi Fructus; UHPLC-ESI-Q-TOF-MS; phenylethanoids; flavonoids; secoiridoids; triterpenoids
Funding
- National Natural Science Foundation of China [81373972, 81573554]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Qing Lan Project of Jiangsu Province
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Ligustri Lucidi Fructus (LLF), the fruit of Ligustrum lucidum Ait. (Oleaceae), has been used as a common herbal medicine in clinical practice in China for nearly 2000 years. In most cases, LLF is prescribed in decoctions in the form of processed products rather than crude drugs. In this study, an ultra-high performance liquid chromatography coupled with electrospray ionization-quadrupole-time of flight-mass spectrometry (UHPLC-ESI-Q-TOF-MS) method was established for rapid separation and identification of multiple constituents in the 80% methanol extract of processed-LLF. A total of 50 compounds (one phenylethanoid, seven phenylethanoid glycosides, seven flavonoids, 25 iridoids, nine triterpenoids and one cyclohexanecarboxylic acid) were either unambiguously identified or tentatively characterized with the aid of authentic standards or published data. Luteolin-7-O-rutinoside, oleoside and secologanoside were detected in LLF for the first time. This study enriches the chemical profiling of processed-LLF and could provide valuable information for the quality control and further investigation of processed-LLF and crude LLF.
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